By Min Kyung-Tai, Karen Chang
Animal experiments have contributed a lot to our figuring out of mechanisms of affliction and are important for deciding upon new remedies. This quantity reports the newest study and advancements during this box. * Discusses new discoveries, methods, and concepts * Contributions from best students and specialists * Reference consultant for researchers all for molecular biology and similar fields
Read Online or Download Animal Models of Human Disease, Volume 100 (Molecular Biology and Translational Science) PDF
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Extra info for Animal Models of Human Disease, Volume 100 (Molecular Biology and Translational Science)
79 As in wild-type prostates, epithelial cells in Pten-null prostate tumors have an increased number of apoptotic cells after the androgen ablation, indicating that the tumor cells still respond to the androgen deprivation. However, the cancer cells continue to proliferate even after androgen withdrawal, which counteracts the effect of apoptosis induced by androgen deprivation. 80 The cells are either heterozygous or homozygous for Pten deletion, but, loss of both Pten alleles is associated with increased anchorage-independent growth in vitro and tumorigenesis in vivo.
The mice develop PIN lesions within a week afterward, which progress rapidly and the tumors invade lymph nodes, liver, lung, and bone by 6 months in an androgen-independent manner. Although cytochrome b heavy chain (gp91-phox) is expressed exclusively in terminally differentiating cells of the myelomonocytic lineage, male gp91-phox T transgenic mice that carry T antigens driven by the gp91-phox promoter unexpectedly express the T antigens in the prostate and develop prostate tumors,26 which are characterized as androgen-independent neuroblastomas.
During the first 14 months, all transgenic animals exhibit multifocal epithelial hyperplasia; about 1/3 of the animals also have areas of low-grade PIN. Between 15 and 24 months, about two-thirds of the mice develop low-grade PIN and about half of the mice develop high-grade PIN lesions. Stromal cells have elevated proliferation activities. The affected stroma consists primarily of the SMC component. The epithelial cells exhibit papillary hyperplasia with atypia displayed in the FGF8b transgenic mice.
Animal Models of Human Disease, Volume 100 (Molecular Biology and Translational Science) by Min Kyung-Tai, Karen Chang