By R. N. Perham (auth.), Prof. Mulchand S. Patel, Dr. Thomas E. Roche, Dr. Robert A. Harris (eds.)
Found in all organisms, the alpha-keto acid dehydrogenase complexes have primary roles in mobile metabolism and are significant websites of rules. the knowledge of the association, functionality and law of those indispensable multienzyme complexes has been tremendously complex through experiences making use of molecular biology and biophysical suggestions. even though those enzyme platforms have a few good points in universal, their variety in gratifying designated organism - or tissue - particular roles is actually striking. those platforms have scientific value in components starting from defects in legislation (linked to diabetes, middle sickness, weight problems, foodstuff defects), to inherited illnesses (inborn error, maple syrup urine ailment) to obtained immune ailments (primary biliary cirrhosis). This e-book brings jointly wide-ranging contemporary findings at the structure(function relationships, gene legislation, and genetic defects of the alpha-keto acid dehydrogenase complexes, particularly the pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and the branched-chain alpha-keto acid dehydrogenase complexes. a large choice of experimental ways including new effects awarded during this booklet should still function a source for commencing to demonstrated investigators within the box in addition to scientists who're drawn to mitochondria, dehydrogenases, kinases, phosphatases, lipoic acid, thiamine pyrophosphate, and enzyme complexes.
Read or Download Alpha-Keto Acid Dehydrogenase Complexes PDF
Best nonfiction_8 books
In so much eventualities of the longer term a customized digital butler appears to be like. This butler not just plays conversation and coordination initiatives but additionally offers tips on find out how to deal with daily difficulties. the purpose of this publication is to discover the necessities of the sort of customized digital butler through asking: what's recognized in regards to the capacities and the desires of getting older humans; which info and communique applied sciences were utilized in assisting/conversing with folks, specifically older ones, and what have been the implications; what are the advantages/disadvantages of digital butlers as almost always software program courses in comparison robots as butlers; and which tools, specially in synthetic intelligence, need to be built additional and within which course to be able to create a digital butler within the foreseeable destiny?
This e-book explores either non parametric and normal statistical rules by means of constructing non parametric approaches in basic occasions. the key target is to offer the reader an intensive intuitive knowing of the ideas underlying nonparametric tactics and a whole appreciation of the homes and working features of these methods coated.
- AB Initio Calculation of Phonon Spectra
- Computational Linguistics: Applications
- Universal Compression and Retrieval
- Protamines: Isolation · Characterization · Structure and Function
- Learning Issues for Intelligent Tutoring Systems
- Stochastic Models in Geosystems
Additional resources for Alpha-Keto Acid Dehydrogenase Complexes
Biochem. Int. 9: 491-499. S. E. (1991) Investigation of the pyruvate dehydrogenase complex using the circular dichroism method. ) 56: 1840-1849. S. E. (1993) Effect of phosphorylation on the catalytic function of muscular pyruvate dehydrogenase complex. ) 58: 1503-1512. G. S. (1995) Mutagenic studies of the phosphorylation sites of recombinant human pyruvate dehydrogenase. Site-specific regulation. J. Bioi. Chem. 270: 14297 -14304. , Kim, H. S. (1995) Overexpression and characterization of human tetrarneric pyruvate dehydrogenase and its individual subunits.
I. o. (1990) Pea leaf mitochondrial pyruvate dehydrogenase complex is inactivated in vivo in a light-dependent manner. Proc. Natl. Acad. Sci. USA 87: 673-676. F. I. (1977) Binding of thiamin thiazolone pyrophosphate to mammalian pyruvate dehydrogenase and its effects on kinase and phosphatase activities. 1. BioI. Chem. 74: 16671674. M. G. (1994) Investigation of the cofactor-binding site of Zymomonas mobilis pyruvate decarboxylase by site-directed mutagenesis. Biochem. 1. 300: 7 -13. , Clark, B.
157: 4167. G. S. (1991) Sequence conservation in the a and ~ subunits of pyruvate dehydrogenase and its similarity to branched-chain a-keto acid dehydrogenase. FEBS Lett. 282: 209-213. S. S. (1992) A mutation in the Ela subunit of pyruvate dehydrogenase associated with variable expression of pyruvate dehydrogenase complex deficiency. Pediat. Res. 32: 169 - l7 4. , Hartmann, U. A. (1972) Neurospora crassa pyruvate dehydrogenase: interconversion by phosphorylation and dephosphorylation. FEBS Lett.
Alpha-Keto Acid Dehydrogenase Complexes by R. N. Perham (auth.), Prof. Mulchand S. Patel, Dr. Thomas E. Roche, Dr. Robert A. Harris (eds.)